研究成果

代表的な発表論文のリストです

Tanaka M, Nakamura T. Targeting epigenetic aberrations of sarcoma in CRISPR era. Genes Chromosomes Cancer, 62:510-525, 2023

Tanaka M, Homme M, Teramura Y, Kumegawa K, Yamazaki Y, Yamashita K, Osato M, Maruyama R, Nakamura T. HEY1-NCOA2 expression modulates chondrogenic differentiation and induces mesenchymal chondrosarcoma in mice. JCI Insight, 8:e160279, 2023

Tanaka M, Chuaychob S, Homme M, Yamazaki Y, Lyu R, Yamashita K, Ae K, Matsumoto S, Maruyama R, Miyagi Y, Yokokawa R, Nakamura T. ASPSCR1-TFE3 orchestrates the angiogenic program of alveolar soft part sarcoma. Nat Commun, 14:1957, 2023

Cidre-Aranaz F, Watson S, Amatruda JF, Nakamura T, Delattre O, de Alava E, Dirksen U, Grunewald TGP. Small round cell sarcomas. Nat Rev Dis Prim, 8:66, 2022

Yoshino S, Tanaka M, Sunami Y, Takahara T, Yamazaki Y, Homme M, Niibori-Nambu A, Osato M, Minami T, Ishihara K, Nakamura T. Trib1 promotes the development of acute myeloid leukemia in a Ts1Cje mouse model of Down syndrome. Leukemia, 36:558-561, 2022.

Sunami Y, Yokoyama T, Yoshino S, Takahara T, Yamazaki Y, Harada H, Nakamura T. BCL11A promotes myeloid leukemogenesis by repressing PU.1 target genes. Blood Adv, 6:1827-1843, 2022.

Kurata M, Onishi I, Takahara T, Yamazazki Y, Ishibashi S, Goitsuka R, Kitamura D, Takita J, Hayashi Y, Largaespada DA, Kitagawa M, Nakamura T. C/EBPb induces B-cell acute lymphoblastic leukemia and cooperates with BLNK mutations. Cancer Sci, 112:4920-4930, 2021.

Yoshino S, Yokoyama T, Sunami Y, Takahara T, Nakamura A, Yamazaki Y, Tsutsumi S, Aburatani H, Nakamura T. Trib1 promotes acute myeloid leukemia progression by modulating the transcriptional programs of Hoxa9. Blood, 137:75-88, 2021.

Tanaka M, Nakamura T. Genetically engineered mouse model in Ewing sarcoma. Methods Mol Biol, 2226:183-189, 2021.

Tanaka M, Nakamura T. Modeling fusion gene-associated sarcoma: advantages for understanding sarcoma biology and pathology. Pathol Int, 71:643-654, 2021.

Tanaka M, Homme M, Yamazaki Y, Ae K, Matsumoto S, Subramanian S, Nakamura T. Cooperation between SS18-SSX1 and miR-214 in synovial sarcoma development and progression. Cancers, 12:324, 2020.

Teramura Y, Tanaka M, Yamazaki Y, Yamashita K, Takazawa Y, Ae K, Matsumoto S, Nakayama T, Kaneko T, Musha Y, Nakamura T. Identification of novel fusion genes in bone and soft tissue sarcoma and their implication in the generation of a mouse model. Cancers, 12:2345, 2020.

Shimizu R, Tanaka M, Tsutsumi S, Aburatani H, Yamazaki Y, Homme M, Kitagawa Y, Nakamura T. EWS-FLI1 regulates a transcriptional program in cooperation with Foxq1 in mouse Ewing sarcoma. Cancer Sci, 109:2907-2918, 2018.

Tanaka M, Homme M, Yamazaki Y, Shimizu R, Takazawa Y, Nakamura T. Modeling alveolar soft part sarcoma unveils novel mechanisms of metastasis. Cancer Res, 77:897-904, 2017.

Yoshimoto T, Tanaka M, Homme M, Yamazaki Y, Takazawa Y, Antonescu CR, Nakamura T. CIC-DUX4 induces small round cell sarcomas distinct from Ewing sarcoma. Cancer Res, 77:2927-2937, 2017.

Tanaka M, Yoshimoto T, Nakamura T. A double-edged sword: the world according to Capicua in cancer. Cancer Sci, 108:2319-2325, 2017.

Yokoyama T, Nakatake M, Kuwata T, Couzinet A, Goitsuka R, Tsutsumi S, Aburatani H, Valk PJM, Delwel R, Nakamura T. MEIS1-mediated transactivation of synaptotagmin like 1 promotes CXCL12/CXCR4 signaling and leukemogenesis. J Clin Invest, 126:1664-1678, 2016.

Nakamura T. The role of Trib1 in myeloid leukaemogenesis and differentiation. Biochem Soc Trans, 43:1104-1107, 2015.

Tanaka M, Yamazaki Y, Kanno Y, Igarashi K, Aisaki K, Kanno J, Nakamura T. Ewing’s sarcoma precursors are highly enriched in embryonic osteochondrogenic progenitors. J Clin Invest, 121:3061-3074, 2014.

Ariki R, Morikawa S, Mabuchi Y, Suzuki S, Nakatake M, Yoshioka K, Hidano S, Nakauchi H, Matsuzaki Y, Nakamura T, Goitsuka R. Homeodomain transcription factor Meis1 is a critical regulator of adult bone marrow hematopoiesis. PLoS One, 9: e87646, 2014.

Yokoyama T, Toki T, Aoki Y, Kanezaki R, Park M, Kanno Y, Takahara T, Yamazaki Y, Ito E, Hayashi Y, Nakamura T. Identification of TRIB1 R107L gain-of-function mutation in human acute megakaryocytic leukemia. Blood, 119: 2608-2611, 2012.

Yokoyama T, Nakamura T. Tribbles in disease: signaling pathways important for cellular function and neoplastic transformation. Cancer Sci, 102: 1115-1122, 2011.

Yokoyama T, Kanno Y, Yamazaki Y, Takahara T, Miyata S, Nakamura T. Trib1 links the MEK1/ERK pathway in myeloid leukemogenesis. Blood, 116, 2768-2775, 2010.

Tanaka M, Jin G, Yamazaki Y, Takahara T, Takuwa M, Nakamura T. Identification of candidate cooperative genes of the Apc mutation in transformation of the colon epithelial cell by retroviral insertional mutagenesis. Cancer Sci, 99, 979-985, 2008.

Jin G, Yamazaki Y, Takuwa M, Takahara T, Kaneko K, Kuwata T, Miyata S, Nakamura T. Trib1 and Evi1 cooperate with Hoxa and Meis1 in myeloid leukemogenesis. Blood, 109, 3998-4005, 2007.

Kawamura-Saito M, Yamazaki Y, Kaneko K, Kawaguchi N, Kanda H, Mukai H, Gotoh T, Motoi T, Fukayama M, Aburatani H, Takizawa T, Nakamura T. Fusion between CIC and DUX4 up-regulates PEA3 family genes in Ewing-like sarcomas with t(4;19)(q35;q13) translocation. Hum Mol Genet, 15, 2125-2137, 2006.

Nakamura T. Retroviral insertional mutagenesis identifies oncogene cooperation. Cancer Sci, 96, 7-12, 2005.

Iwasaki M, Kuwata T, Yamazaki Y, Jenkins NA, Copeland NG, Osato M, Ito Y, Kroon E, Sauvageau G, Nakamura T. Identification of cooperative genes for NUP98-HOXA9 in myeloid leukemogenesis using a mouse model. Blood, 105, 784-793, 2005.

Yamaguchi S, Yamazaki Y, Ishikawa Y, Kawaguchi N, Mukai H, Nakamura T. EWSR1 is fused to POU5F1 in a bone tumor with translocation t(6;22)(p21;q12). Genes Chromosomes Cancer, 43, 217-222, 2005.

Hisa T, Spence SE, Rachel RA, Fujita M, Nakamura T, Ward JM, Devor-Henneman DE, Saiki Y, Kutsuna H, Tessarollo L, Jenkins NA, Copeland NG. Hematopoietic, angiogenic and eye defects in Meis1 mutant animals. EMBO J, 23, 450-459, 2004.

Fujino T, Suzuki A, Ito Y, Ohyashiki K, Hatano Y, Miura I, Nakamura T. Single translocation and double chimeric transcripts: Detection of NUP98-HOXA9 in myeloid leukemias with HOXA11 or HOXA13 breaks of the chromosomal translocation t(7;11)(p15;p15). Blood, 99, 1428-1433, 2002.

Nakamura T, Yamazaki Y, Saiki Y, Moriyama M, Largaespada DA, Jenkins NA, Copeland NG. Evi9 encodes a novel zinc finger protein that interacts with BCL6, a known human B-cell proto-oncogene. Mol Cell Biol, 20, 3178-3186, 2000.

Nakamura T, Yamazaki Y, Hatano Y, Miura I. NUP98 is fused to PMX1 homeobox gene in human AML with chromosome translocation t(1;11)(q23;p15). Blood, 94, 741-747, 1999.

Nakamura T, Jenkins NA, Copeland NG. Identification of a new family of Pbx-related homeobox genes. Oncogene, 13, 2235-2242, 1996.
 

Nakamura T, Largaespada DA, Shaughnessy JD, Jenkins NA, Copeland NG. Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukemias. Nat Genet, 12, 149-153, 1996.

Nakamura T, Largaespada DA, Lee MP, Johnson LA, Ohyashiki K, Toyama K, Chen SJ, Willman CL, Chen I-M, Feinberg AP, Jenkins NA, Copeland NG, Shaughnessy JD. Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukemia. Nat Genet, 12, 154-158, 1996.